profhilo

What Is Profhilo? What Does It Do, How Long Does It Last, and Who Is It For?

As we age, the skin naturally loses collagen, elastin, and moisture, resulting in dryness, reduced elasticity, fine lines, and skin laxity. These changes gradually affect the skin’s firmness, texture, and overall youthful appearance.

While many aesthetic treatments are available to improve skin quality, Profhilo® has become one of the most popular innovations in injectable skin remodeling. Rather than adding volume or changing facial contours like traditional dermal fillers, Profhilo works by remodeling the skin from within. Its high-concentration Hyaluronic Acid (HA) stimulates collagen and elastin production while deeply hydrating the skin, helping to restore firmness, elasticity, and a naturally healthy, radiant complexion.

What is Profhilo®?

Profhilo® is an advanced injectable bio-remodeling treatment and collagen biostimulator formulated with one of the highest concentrations of Hyaluronic Acid (HA) available. Rather than adding volume like a traditional dermal filler, Profhilo® works by improving the skin’s structure from within through a process known as Bio-Remodeling.

The treatment stimulates collagen and elastin production while deeply hydrating the skin, resulting in firmer, smoother, and healthier-looking skin. It also helps improve skin elasticity, soften fine lines, and enhance the appearance of mild acne scars, making it an excellent option for comprehensive skin rejuvenation.

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What Makes Profhilo® Unique?

Profhilo® contains 64 mg of Hyaluronic Acid in a 2 mL syringe (32 mg/mL)—one of the highest HA concentrations available for injectable skin rejuvenation.

Its unique formulation is produced using the patented NAHYCO® Technology, a thermal manufacturing process that combines both high- and low-molecular-weight hyaluronic acid into a Hybrid Cooperative Complex (HCC).

This innovative technology allows the product to:

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  • Spread evenly throughout the skin
  • Remain highly stable without chemical cross-linking
  • Degrade gradually over time
  • Stimulate collagen and elastin production
  • Improve skin hydration and elasticity

Profhilo® vs. Dermal Fillers

Although both Profhilo® and dermal fillers are made from Hyaluronic Acid (HA), they are designed for different purposes.

Profhilo® uses non-crosslinked HA combined with NAHYCO® Technology, allowing it to diffuse evenly throughout the skin rather than staying in one location. Its primary purpose is to restore skin quality, stimulate cellular activity, improve elasticity, and enhance the skin’s ability to retain moisture.

Dermal fillers, on the other hand, are designed to restore lost facial volume, contour facial features, and correct deeper folds or hollowness. Patients seeking structural enhancement or facial reshaping are generally better suited for dermal filler treatments.

Recommended Treatment Protocol

Each syringe of Profhilo® contains 2 mL of product.

For optimal results, the recommended treatment protocol is:

  • 2 treatment sessions
  • Treatments performed 4 weeks apart

Patients with more advanced skin aging or concerns such as acne scarring may benefit from 3 treatment sessions, depending on the physician’s assessment.

How Long Do the Results Last?

After completing the initial two-session protocol, results typically last 6–12 months, depending on individual skin condition, lifestyle, and post-treatment care.

To maintain optimal skin quality, a maintenance treatment once every 12 months is generally recommended, or as advised by your physician.

When Will You See Results?

Most patients begin to notice improvements within 7–14 days, as the skin becomes more hydrated, radiant, and refreshed.

The most noticeable improvements develop over 1–2 months, as collagen and elastin production increases. At this stage, the skin appears:

  • More hydrated and luminous
  • Firmer and more elastic
  • Smoother with improved texture
  • Fine lines and small wrinkles become less noticeable
  • Naturally rejuvenated with a healthier, more youthful appearance

Benefits of Profhilo®

  • Deeply hydrates the skin
  • Stimulates collagen and elastin production
  • Improves skin firmness and elasticity
  • Enhances overall skin quality
  • *Softens fine lines
  • Improves skin texture and mild acne scars
  • Restores a healthy, radiant complexion
  • Provides natural-looking rejuvenation without adding facial volume